Cell Signalling Biology Clear science, from cell to signal.

Cell Signalling Biology

Clear science, from cell to signal.

Latest Articles

Standing on the Platform at Clapham Junction: A Molecular Account of the Morning Delay
Disease Mechanisms

Standing on the Platform at Clapham Junction: A Molecular Account of the Morning Delay

The delayed train is a trivial inconvenience, yet the body answers it with the same machinery evolved for mortal danger. We trace the sympathetic signalling cascade from hypothalamus to adrenaline surge to cortisol's slower arrival — and ask what repeated, unrecovered activation does to a system built for emergencies.
When the Signal Loses Its Sting: Desensitisation, from Bakery Kitchens to Blue Inhalers
Pharmacology Explainers

When the Signal Loses Its Sting: Desensitisation, from Bakery Kitchens to Blue Inhalers

Cells are bombarded with chemical messages that demand attention, yet they cannot afford to respond at full strength forever. This article examines desensitisation and adaptation — the receptor-level machinery that lets a cell lower the volume — and why the same process explains both the fading smell of fresh bread and the waning power of a salbutamol inhaler.
The Line That Won't Go Dead: Immune Signalling and the Failure to Stand Down
Disease Mechanisms

The Line That Won't Go Dead: Immune Signalling and the Failure to Stand Down

Every immune response depends as much on a reliable off-switch as on a sharp alarm. This article examines what happens when T cells and cytokine pathways keep transmitting after the threat has gone, using rheumatoid arthritis and multiple sclerosis as clinical case studies, and how UK-led work on checkpoints and JAK inhibitors is restoring the silence.
The Beta Cell's Breakfast Audit: Tracing Every Step from Toast to Insulin
Pharmacology Explainers

The Beta Cell's Breakfast Audit: Tracing Every Step from Toast to Insulin

After a slice of toast or a full English, your pancreatic beta cells perform an extraordinary act of molecular accounting, converting rising blood glucose into a precisely calibrated burst of insulin. We walk the pathway step by step — and examine where GLP-1 drugs such as semaglutide plug into the same circuit.
Silence, Please: Why the End of a Signal Matters as Much as Its Beginning
Pharmacology Explainers

Silence, Please: Why the End of a Signal Matters as Much as Its Beginning

Much of cell signalling science concerns how messages are sent, yet the moment a message stops being heard is equally consequential. This article follows neurotransmitters into the machinery of reuptake and enzymatic destruction, and explains how SSRIs and nerve agents each hijack the same clean-up crew to very different ends.
A Garden Sting, Dissected: The Molecular Choreography of an Allergic Reaction
Disease Mechanisms

A Garden Sting, Dissected: The Molecular Choreography of an Allergic Reaction

Few British summers pass without someone leaping off a deckchair after a bee encounter. Behind the yelp lies a precisely choreographed signalling cascade — one that explains how the immune system recognises a threat, amplifies its message, and occasionally overreacts.
Fifty Milliseconds to Safety: The Remarkable Journey of a Withdrawal Reflex
Disease Mechanisms

Fifty Milliseconds to Safety: The Remarkable Journey of a Withdrawal Reflex

Touch a hot pan and your hand is moving before you have consciously registered any pain. We trace that signal from fingertip to spinal cord and back, and ask what happens when a disease such as multiple sclerosis interferes with the same pathway.
Ethanol at the Synapse: The Molecular Story Behind Every Round Bought
Pharmacology Explainers

Ethanol at the Synapse: The Molecular Story Behind Every Round Bought

Alcohol is one of the few drugs Britons can buy with their shopping, yet its actions at the synapse remain widely misunderstood. From GABA enhancement to glutamate rebound, we follow ethanol's molecular conversation — and explain why the morning after feels so punishing.
Chemistry of the Swollen Ankle: Reading the Distress Signals Beneath a Bruise
Disease Mechanisms

Chemistry of the Swollen Ankle: Reading the Distress Signals Beneath a Bruise

A twisted ankle on the Pennine Way sets off a molecular emergency broadcast within minutes. We trace the inflammatory signals from damaged tissue to arriving immune cell — and ask what happens when the alarm refuses to switch off.
Second Brain, First Post: What Your Gut Microbes Are Actually Saying to Your Head
Pharmacology Explainers

Second Brain, First Post: What Your Gut Microbes Are Actually Saying to Your Head

The gut microbiome produces chemical signals that reach the brain — but separating the rigorous science from the wellness-industry marketing requires a pharmacologist's eye. Here is what the evidence on short-chain fatty acids, tryptophan and the vagus nerve genuinely supports.
Inside the Cell's Post Office: The Nobel Story of Cyclic AMP
Pharmacology Explainers

Inside the Cell's Post Office: The Nobel Story of Cyclic AMP

In 1971, Earl Sutherland received the Nobel Prize for revealing how hormones whisper to cells through a tiny internal courier, cyclic AMP. This article traces the detective work behind the second messenger concept and explains why the discovery still shapes British pharmacology half a century on.
Breakthrough or Hype? A Field Guide to Reading Signalling Stories in the News
Disease Mechanisms

Breakthrough or Hype? A Field Guide to Reading Signalling Stories in the News

'Scientists hail breakthrough' is a phrase UK readers meet weekly, but signalling research rarely moves at headline speed. This guide offers a practical checklist for students and writers to distinguish robust cell biology from overcooked press releases.
From Photon to Circadian Clock: Tracing Light's Signalling Journey Through the Retina
Pharmacology Explainers

From Photon to Circadian Clock: Tracing Light's Signalling Journey Through the Retina

Light is the body's most powerful external signal, governing vision, sleep timing and even seasonal mood. This article follows a photon's journey through phototransduction and the circadian system, and considers the pharmacological implications for treating sleep disorders and seasonal affective disorder.
Winter, Fever and the Hypothalamus: Inside the Body's Central Heating Controller
Disease Mechanisms

Winter, Fever and the Hypothalamus: Inside the Body's Central Heating Controller

As temperatures fall across Britain, the body mounts a coordinated hormonal response to defend its core temperature. This article traces the signalling circuitry of thermoregulation, from thyroid hormones and adrenaline to the fever response, and examines what happens when the system fails.
Pilgrimages of the Penicillin Age: Where Britain Shaped the Science of Cell Signalling
Disease Mechanisms

Pilgrimages of the Penicillin Age: Where Britain Shaped the Science of Cell Signalling

Britain's laboratories and museums hold a remarkable share of the discoveries that founded modern signalling science. This tour through five landmark achievements — and the places you can still visit today — traces how cAMP, kinases and more changed medicine, and where UK-funded research is heading next.
Special Delivery: How Cells Address, Send and Read Chemical Messages
Pharmacology Explainers

Special Delivery: How Cells Address, Send and Read Chemical Messages

Viewing the body's chemical messengers through the lens of a national postal service, this explainer follows a signal from its point of origin to its final destination. Ideal preparation for A-level and undergraduate examinations, with examples drawn directly from UK exam specifications.
The Medicine Cabinet as a Signalling Laboratory: Five Familiar Drugs with Cellular Jobs
Pharmacology Explainers

The Medicine Cabinet as a Signalling Laboratory: Five Familiar Drugs with Cellular Jobs

Beta blockers, SSRIs, statins and other everyday prescriptions all work by adjusting the same signalling pathways students meet in the textbook. This accessible guide connects the molecules in your local pharmacy to the receptors and cascades they quietly manage.
Disease Mechanisms

When the Conversation Never Stops: How Broken Signalling Fuels Cancer

Cancer is often described as uncontrolled growth, but at the molecular level it is a failure of communication. This article traces how mutations in receptors such as EGFR and downstream proteins like RAS convert a carefully regulated dialogue into permanent, growth-driving static.