Module 12: Figure signalsome remodelling

Relationship between stimulus strength and signalling responses for normal and remodelled signalsomes.

The signalsome that makes up each signalling system has a normal operational range (green curve) over which it responds to changes in stimulus strength with a characteristic dose–response curve. If the signalsome is remodelled, this sensitivity will change such that the signalsome becomes either sensitized (red curve) or desensitized (blue curve). Such shifts in sensitivity may be responsible for various disease states.