High resolution

Module 12: Figure signalling pathways in Parkinson's disease

Parkinson's disease (PD) signalling defects in dopaminergic neurons.

The signalling mechanisms of dopaminergic neurons located in the substantia nigra pars compacta (SNc) undergo numerous changes (as illustrated by the yellow arrows) that arise either spontaneously, as occurs in sporadic PD or they are induced by mutations of genes as occurs in familial PD. Many of these changes result in a reduction in mitochondrial function that is the main cause of neuronal cell death.