High resolution

Module 12: Figure reversal of calcium signalling in neurodegeneration

Reversal of calcium signalling in neurodegeneration.

The neurodegeneration in mouse models of Alzheimer's disease (AD) can be reversed by a variety of agents (shown in the white boxes). Consistent with the calcium hypothesis of AD, many of these agents act to reduce the abnormal elevation in intracellular calcium that is proposed to be the cause of memory loss and increased apoptosis.