Module 12: Figure remodelling the neural signalsome
Li+ remodels the neural inositol 1,4,5-trisphosphate (InsP3)/Ca2+ signalsome.
The inositol depletion hypothesis suggests that the neural inositol 1,4,5-trisphosphate (InsP3)/Ca2+ signalsome that is responsible for normal neural signalling is remodelled so that it induces excessive metabotropic receptor signalling that leads to manic-depressive illness. Li+ and valproate correct the signalsome, such that it can return to transmitting normal InsP3/Ca2+ signalling. The time taken to remodel this signalling system may account for the long time lag for Li+ to exert its effects on manic-depressive illness.