Module 12: Figure remodelling the cardiac signalsome

Congestive heart failure (CHF) results from a two-step remodelling of the cardiac signalsome.

Hypertrophic conditions, such as mechanical overload, loss of myocytes and endocrine factors, bring about a remodelling of the cardiac signalsome that begins with compensated hypertrophy, which is then followed by an irreversible step to produce the decompensated hypertrophy characteristic of congestive heart failure (CHF).