Module 12: Figure phenotypic and genotypic remodelling

Phenotypic and genotypic remodelling of cell-specific signalsome.

Each cell-specific signalsome is designed to generate a typical output signal in order to carry out its particular cellular control mechanisms. This signalsome can be remodelled through phenotypic (top) or genotypic (bottom) modifications to produce output signals that are either too strong or too weak. Such modified signalsomes are responsible for many disease states.