Module 12: neuronal Ca2+ signals in AD mice



Ca2+ signals in neurons from Alzheimer's disease mouse models.

Ca2+ signals were induced either by the photolysis of caged InsP3 (arrows in A–D) or by a depolarizing current (bars in E–H) that induced a train of action potentials. A and E, non-transgenic controls (NonTg); B and F, transgenic mouse neurons carrying mutations in APP and tau (APPTau); C and G, transgenic mouse neurons carrying mutations in presenilin 1 (PS1KI); D and H, transgenic mouse neurons carrying mutations in APP, tau and presenilin 1 (3xTG-AD). Reproduced from Stutzmann, G.E., Smith, I., Caccamo, A., Oddo, S., LaFerla, F.M. and Parker, I. (2006) Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult and aged Alzhemier's disease mice. J. Neurosci. 26:5180–5189. Copyright (2006), with permission from the Society of Neuroscience; see Stutzmann et al. 2006.