Module 12: Figure chromatin organization
The two types of chromatin are spatially segregated in the nucleus. The heterochromatin is associated with a linker of nucleoskeleton and cytoskeleton (LINK) complex, which is a scaffolding network consisting of proteins such as the lamins that constitute the nuclear lamina, lamin B receptor (LBR), heterochromatin protein 1 (HP1), emerin, barrier-to-autointegration factor (BAF) and SUN1. The SUN1 is connected to the actin-binding protein nesprin. The euchromatin chromosomal regions extend into the nucleus where genes from different chromosomes (e.g. chromosomes 1–3) come together in a localized region, so called transcription factories, where protein expression is optimized by sharing various transcription machinery components.