Module 12: Figure Inflammation and Alzheimer's disease
Inflammation and Alzheimer's disease.
Inflammation seems to play an important role in the development of Alzheimer's disease, which is triggered by the accumulation of amyloid β (Aβ), which aggregates into oligomers that have a number of actions. The Aβ can act directly on the neurons to bring about the elevations in Ca2+ that have been linked to the initial phase of memory loss and the subsequent increase in apoptosis that characterizes the development of AD. The Aβ can also induce inflammatory responses in the neighbouring microglia and astrocytes that activate processes that influence this dysregulation of Ca2+ signalling. Vitamin D3 can alleviate AD development by inhibiting the inflammatory responses and by increasing the expression of processes that reduce the elevation of Ca2+ within neurons. See the text for further details of all these processes.