Module 12: Figure insulin resistance

Insulin resistance.

A build-up of free fatty acids (FFAs) initiates insulin resistance through a number of mechanisms that all impinge on changes in the insulin signalling pathway in the various cell types that play a role in energy storage, such as the white fat cells, skeletal muscle and liver. An inability to cope with the build-up of glucose in the blood places great pressure on the β-cells that often collapse resulting in the onset of diabetes. See the text for details of the proposed mechanisms that links excessive energy consumption to insulin resistance.