High resolution

Module 12: Figure astrocyte-induced neuronal death

Astrocyte-induced neuronal cell death hypothesis.

The hypothesis is that β-amyloid peptides (Aβ) acting on astrocytes bring about an increase in Ca2+ entry and may also activate NADPH oxidase to generate superoxide (O2) that then severely depletes the astrocyte level of GSH, with a corresponding decrease in neuronal GSH because neurons receive their GSH from astrocytes. This decline in neuronal GSH will greatly increase their sensitivity to oxidation-induced cell death. Reproduced from Biochim. Biophys. Acta, Vol. 1742, Abramov, A.Y., Canevari, L. and Duchen, M.R., Calcium signals induced by amyloid β peptide and their consequences in neurons and astrocytes in culture, pp. 81–87. Copyright (2004), with permission from Elsevier; see Abramov et al. 2004.