High resolution

Module 12: Figure amyloids and Ca2+ signalling

Amyloids and Ca2+ signalling.

The calcium hypothesis of Alzheimer's disease suggests that alterations in amyloid processing results in the formation of Aβ oligomers that bring about an overall increase in Ca2+ signalling that then induces memory loss, neuronal apoptosis and the onset of dementia. The way in which the amyloidogenic pathway functions to remodel the Ca2+ signalling system is described in Module 12: Figure amyloid cascade hypothesis.