Module 12: Figure H pylori nano-syringe
Type IV secretion system of H. pylori.
H. pylori assemble a secretion apparatus that has 32 proteins some of which produce a long tube (pilus) that has a cytotoxin-associated gene A ligand (CagL) protein with an RGD motif that makes contact with and activates the α5β1 integrin complex on the surface of the host cell. This binding to the α5β1 integrin complex initiates the activation of host cell signalling components that play a role in the injection and activation of the cancer-associated protein CagA. Reproduced from Kwok et al 2007.