High resolution

Module 11: Figure inflammation

Summary of the inflammatory response to tissue damage and pathogens.

The innate immune system is triggered by signals derived from tissue damage and invading pathogens to activate cells such as the macrophages, neutrophils, mast cells, blood platelets and endothelial cells that contribute to a co-ordinated series of responses to both remove the pathogens and to repair damaged tissues. The endothelial cells are shown in three states: normal flattened shape (blue), contracted to increase endothelial permeability (light yellow) and damaged cells (bright yellow), where platelet aggregation occurs during formation of the haemostatic plug. Details of these responses are described in the text.