High resolution

Module 11: Figure FcεRI mast cell signalling

The mast cell FcεRI complex relays information to a number of signalling pathways.

The FcεRI complex is composed of α, β and γ subunits that lack enzymatic activity. Signal transduction is carried out by non-receptor tyrosine kinases (Fyn, Lyn and Syk) that phosphorylate different elements that then recruit the signalling components of a number of pathways to control phospholipase A2 (PLA2) activation, granule release and gene transcription, as described in the text.