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Module 10: Figure synaptic signalling mechanisms



The spines on hippocampal CA1 neurons and Purkinje cells have a distinctive set of signalling components responsible for generating neuron-specific postsynaptic responses.

The hippocampal CA1 neuron is activated by glutamate released from the Schaffer collateral. Similarly, Purkinje cells are activated by glutamate released from the synaptic endings of parallel fibres. However, there are marked differences in the way glutamate acts in these two examples, as described in the text.