High resolution

Module 10: Figure mossy fibre presynaptic release

Spontaneous release of transmitter from mossy fibre boutons.

The trace (top left) shows the frequency of miniature excitatory postsynaptic currents (mEPSCs) in response to the addition and removal of 20 μM nicotine (first and second arrows respectively). The other traces are expanded versions of segments of control, the high-frequency large amplitude mEPSCs induced by nicotine and the recovery after washing out the nicotine. Reproduced from Neuron, Vol. 38, Sharma, G. and Vijayaraghavan, S., Modulation of presynaptic store calcium induces release of glutamate and postsynaptic firing, pp. 929–939. Copyright (2003), with permission from Elsevier; see Sharma and Vijayaraghavan 2003.