High resolution

Module 10: Figure location of magnocellular neurons

Location and structure of magnocellular neurons.

a. The cell bodies of the two types of magnocellular neurons (MCNs) (oxytocin and vasopressin neurons) are located in the supraoptic nucleus (SON), which lies close to the optic chiasm (OC), and the paraventricular nucleus (PVN) located next to the third cerebral ventricle (3V). b. Each MCN has 1–3 dendrites (D) that extend down to form an interconnected web within the ventral glial lamina. c. A typical dendrite (D) showing the numerous large dense-core vesicles (LDCVs) that contain either oxytocin or vasopressin. The arrows indicate examples of the exocytotic events responsible for the dendritic release of oxytocin and vasopressin. Reproduced from Ludwig, M. and Pittman, Q.J. (2003) Talking back: dendritic neurotransmitter release. Trends Neurosci. 26:255–261. Copyright (2003), with permission from Elsevier; see Ludwig and Pittman 2003.