Module 10: Figure hippocampal synapse

The structural organization of a typical synapse from the CA1 region of the hippocampus.

The presynaptic endings are loaded with synaptic vesicles, whereas the postsynaptic endings (i.e. the spines) are relatively empty, except for the spine apparatus. The arrows point to extensions of the spine apparatus that come into close contact with the postsynaptic density (PSD). The molecular organization of the PSD is illustrated in Module 10: Figure postsynaptic density). Reproduced, with permission, from Spacek, J. and Harris, K.M. (1997) Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J. Neurosci. 17:190–203. Copyright (1997) by the Society for Neuroscience; see Spacek and Harris 1997.