Module 10: Figure hippocampal interneurons

Hippocampal interneurons.

The hippocampus has two main cell types: pyramidal cells (e.g. granule cells, CA1 and CA3 neurons) and a large number of inhibitory interneurons. These interneurons express different signalling components and can also be distinguished by the way their axons (shown in red) and dendrites (shown in black) terminate in different regions of the hippocampus. These four regions are colour-coded: stratum oriens (pink), stratum pyramidale (blue), stratum radiatum (green) and stratum lacunosum-moleculare (yellow). CB, calbindin; CCK, cholycystokinin; M2, muscarinic receptor type 2; mGluR1a, metabotropic glutamatergic receptor 1a; NPY, neuropeptide Y; PV, parvalbumin; Sst, somatostatin; VIP, vasoactive intestinal peptide; vGLUT3, vesicular glutamate transporter 3. Some of the interneurons send axons out to innervate neurons in other regions of the hippocampus such as the dentate gyrus (DG) or to other brain regions such as the subiculum (Sub) and septum. Information for this figure was taken from Figure 1 in Somogyi and Klausberger (2005).