High resolution

Module 10: Figure dorsolateral prefrontal cortex

Dorsolateral prefrontal cortex neural circuitry.

The neural circuitry contains populations of excitatory pyramidal neurons (blue) that have a main axon that innervates the association cortex and collateral axons that convey excitation (blue arrow) to a diverse population of inhibitory interneurons (red). The latter have branching axons that not only innervate other inhibitory interneurons, but also innervate the pyramidal neurons (red arrows) at the axon initial segment (AIS), the soma and the dendrites. These cortical local circuits also receive excitatory inputs (yellow arrow) from neurons located in the mediodorsal thalamus. This Figure is based on information obtained from Lewis et al. (2005) and Ross et al. (2006).