Module 10: Figure dendritic endoplasmic reticulum

Organization of the endoplasmic reticulum (ER) in a dendrite and spine.

A three-dimensional reconstruction of the endoplasmic reticulum (ER) is shown, taken from a segment of a dendrite with a small connection (bottom right) that extends into a spine, where it forms the spine apparatus. Note the narrow connection that would pass through the stalk region of the spine. In the lower part of the figure, the plasma membrane of the spine has been included. Reproduced, with permission, from Spacek, J. and Harris, K.M. (1997) Three-dimensional organization of smooth endoplasmic reticulum in hippocampal CA1 dendrites and dendritic spines of the immature and mature rat. J. Neurosci. 17:190–203. Copyright (1997) by the Society for Neuroscience; see Spacek and Harris 1997.