High resolution

Module 10: Figure LTD timing

The role of inositol 1,4,5-trisphosphate (IP3) in timing the coincidence window between parallel fibre and climbing fibre firing during the induction of long-term depression (LTD).

This is an example of input-specific signalling, because only those spines that receive a parallel input are susceptible to the subsequent signal from the climbing fibre to bring about long-term depression (LTD). A–D illustrate the proposed sequence of events that occur during LTD at the parallel fibre/Purkinje cell synapse, as described in the text.