High resolution

Module 10: Figure respiratory pacemaker mechanism

Pacemaker mechanisms of pre-Bötzinger complex pacemaker neurons.

The ‘group pacemaker hypothesis’ is based on the individual pre-Bötzinger complex neurons interacting with each other through a glutamatergic mechanism operating through both AMPARs and metabotropic mGluR5 receptors to ensure that they are coupled to their neighbours so that the circuit can generate a unified output signal. Pacemaker activity also depends on positive-feedback interactions through a number of channels as described in the text. This Figure was constructed based on information contained in Peña et al., 2004, Ramirez et al., 2004, Feldman and Del Negro, 2006, Pace et al., 2007 and Del Negro et al., 2011.