High resolution

Module 10: Figure granule cell neurogenesis

Neurogenesis of granule cell neurons in the dentate gyrus region of the hippocampus.

Putative stem cells in the subgranular zone (SGZ) proliferate continuously to provide a population of neuronal progenitor cells that have a neuronal lineage, but retain the capacity to proliferate. After several rounds of proliferation, these progenitors stop proliferating and then migrate into the granular cell layer (GCL), where they differentiate into fully functional granular cells. During this process of differentiation, the new neurons extend dendrites out into the molecular layer (ML) and an axon, which is the mossy fibre projection (mfp), grows out to innervate the hippocampal CA3 neurons, thus forming a part of the trisynaptic circuit (Module 10: Figure hippocampus). Reproduced from Biol. Psychiatry, Vol. 56, Duman, R.S., Depression: a case of neuronal life and death, pp. 140–145. Copyright (2004), with permission from the Society of Biological Psychiatry; see Duman 2004.