High resolution

Module 10: Figure GnRH neuron

GnRH neuronal activation hypothesis.

The proposed mechanism for gonadotropin-releasing hormone (GnRH) activation. GnRH is released during bursts of neuronal activity that occur with periodicities of 30–60 min. Each burst seems to depend on the spontaneous release of Ca2+ from the intracellular stores. This pulse of Ca2+ causes the pacemaker depolarization that initiates each burst of action potentials. See text for further details.