High resolution

Module 9: Figure proliferation signalling network

Control of cell proliferation by a network of signalling mechanisms.

The hub of this network is the cell cycle, during which proliferative competent cells, such as stem cells, traverse the cell cycle from which they emerge as two daughter cells that then face a number of possible fates. They can re-enter the cell cycle or they can differentiate. Various stresses acting on the p53 system can direct cells towards senescence or apoptosis. Cell proliferation is controlled by a number of signalling systems that act to regulate different components of the cell cycle. This figure illustrates how the various signalling systems outlined in Module 9: Figure cell cycle network interface with the cell cycle by targeting the different cyclin molecules that drive the cell cycle.