Module 9: Figure immunological synapse structure
An immunological synapse formed between a T cell and an antigen-presenting cell.
The cells have been stained with an antibody directed against talin (green), which highlights the outer ring of adhesive elements that constitute the peripheral supramolecular activation cluster (pSMAC). An antibody against protein kinase Cθ (PKCθ) has stained the inner core of signalling components (red), which make up the central SMAC (cSMAC), as illustrated in Module 9: Figure immunological synapse. The synapse is viewed in two orientations. In the top panels (a and b), it is seen from the side (i.e. the x–y axis), whereas in panels d–f, it is seen from the top (i.e. the x–z axis), which clearly shows the bull's-eye appearance of the synapse. Reproduced by permission from Macmillan Publishers Ltd: Nature, Monks, C.R.F., Freiberg, B.A., Kupfer, H., Sciaky, N. and Kupfer, A. (1998) Three-dimensional segregation of supramolecular activation clusters in T-cells. 395:82–86; http://www.nature.com; see Monks et al. 1998.