Module 9: Figure VEGF-induced proliferation
Control of endothelial cell proliferation, NO production and survival by the vascular endothelial growth factor (VEGF).
Endothelial cell activation by vascular endothelial growth factor (VEGF) depends upon its binding and dimerization of two VEGF receptor 2 (VEGFR2) monomers. The latter are tyrosine kinase-linked receptors that have an extracellular domain composed of seven immunoglobulin homology domains and an intracellular tyrosine kinase domain split by a kinase insert sequence. Following receptor dimerization, these kinase regions phosphorylate each other to provide the phosphotyrosine docking sites responsible for initiating the activation of a number of signalling pathways.