High resolution

Module 9: Figure T cell signalling map

A spatiotemporal map of T cell activation.

Signalling begins at the top left with the major histocompatibility complex II (MHCII) presenting the antigen (red) to the T cell receptor (TCR) complex, which then initiates a sequence of events summarized in the green panel on the left of the figure. The sequence begins with the TCR interacting through various transducers to activate signalling cassettes, which relay information into the nucleus through cytosolic messengers to induce gene transcription. Activation of these early gene products sets up an autocrine loop to put in place the interleukin-2 (IL-2) signalling system that activates additional signalling cassettes to complete the signalling cascade by inducing DNA synthesis. The names and abbreviations of all the components of this signalling map are described in Module 9: Table T cell signalling toolkit.