Module 9: Figure T cell Ca2+ signalling
The role of Ca2+ signalling in lymphocyte proliferation.
Antigen initiates the proliferative process by binding to the T cell receptor (TCR), which activates phospholipase Cγ1 (PLCγ1) to hydrolyse PtdIns4,5P2 to generate inositol 1,4,5-trisphosphate (InsP3). InsP3 binds to the InsP3 receptor (InsP3R) to release Ca2+ from the endoplasmic reticulum (ER) and this initiates the signalling cascade described in the text. The way in which Ca2+ acts to stimulate the transcription factor nuclear factor of activated T cells (NFAT) is described in Module 4: Figure NFAT activation. An animated version of this figure is available.