High resolution

Module 9: Figure Rb–E2F interactions

The domain structure of the E2F family of transcription factors and their Rb family-binding partners.

All the E2F transcription factors have a DNA-binding domain (DB), and most of them also have a dimerization domain (DIM). The Rb family-binding domain (green) located in the C-terminal region of the transcriptional activators E2F1–E2F3 is responsible for binding retinoblastoma protein (Rb), whereas p107 and p130 bind to a similar domain on the repressors E2F4 and E2F5. E2F6 and E2F7 do not bind pocket proteins, but E2F6 does bind to the Polycomb group of proteins (PcG). The E2F1–E2F3 isoforms have a nuclear localization signal (NLS), whereas E2F4 and E2F5 have two nuclear export signals (NESs).