Module 9: Figure InsP3 receptors and cell cleavage

Induction of an extra-cleavage furrow by injecting microsomes rich in inositol 1,4,5-trisphosphate (InsP3) receptors close to the membrane.

The microsomes were injected into one cell of a Xenopus embryo after the first cleavage (A). By the time of the next cleavage, an extra furrow appeared at the site where the inositol 1,4,5-trisphosphate (InsP3)-rich microsomes had been deposited. Reproduced from Dev. Biol., Vol. 214, Mitsuyama, F., Sawai, T., Carafoli, E. Furuichi, T. and Mikoshiba, K., Microinjection of Ca2+ store-enriched microsome fractions to dividing newt eggs induces extra-cleavage furrows via inositol 1,4,5-trisphosphate-induced Ca2+ release, pp. 160–167. Copyright (1999), with permission from Elsevier; see Mitsuyama et al. 1999.