High resolution

Module 9: Figure Fanconi anaemia pathway

Fanconi anaemia pathway in DNA repair and cell cycle control.

The Fanconi anaemia pathway functions in DNA repair, particularly in response to DNA crosslinks (vertical red line). The Fanconi anaemia complementation group (FANC) proteins operate as part of two macromolecular complexes that are drawn into such regions when DNA replication is stalled at the crosslinks. Complex 1 (green proteins) has the ubiquitin ligase (L) that ubiquitinates FANCD2, which is part of complex 2 (yellow proteins). Monoubiquitination of the FANCD2 is particularly important in the activation of this pathway. The information used to construct this figure was taken from Kennedy and D'Andrea (2009).