Module 9: Figure T cell actin scaffold



Formation of an actin scaffold at an immunological synapse.

At stage a, the T cell has made contact with the antigen-presenting cells, and the T cell receptor has begun to assemble the signalling components [e.g. Src homology 2 domain-containing leukocyte protein of 76 kDa (SLP-76), Nck, Vav, Wiskott–Aldrich syndrome protein (WASP) and actin-related protein 2/3 (Arp2/3) complex] necessary to form actin filaments, as shown in b. In c, myosin II begins a contraction process that pulls together the individual actin scaffolds associated with each receptor complex to produce the mature synapse shown in the panel at the bottom. The signalling components of the T cell receptor complex are shown in Module 9: Figure TCR signalling. Reproduced by permission from Macmillan Publishers Ltd: Nat. Immunol. Dustin, M.L. and Cooper, J.A. (2000) The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signalling. 1:23–29. Copyright (2000); http://www.nature.com/ni; see Dustin and Cooper 2000.