Module 9: Figure target of rapamycin signalling
Integration of growth factor and nutrient signalling by the target of rapamycin (TOR).
The target of rapamycin (TOR) is a major integrative serine/threonine protein kinase that responds to information coming in from growth factor receptors and from metabolic signalling pathways that assess the nutritional status of the cell. All this information is integrated by the tuberous sclerosis complex 1 and 2 (TSC1 and TSC2), which then relay signals to TOR through the Ras homologue enriched in brain (Rheb) protein. TOR acts through a number of targets to control the rate of protein synthesis. TOR also has an important role to inhibit autophagy (Module 11: Figure autophagy).