High resolution

Module 9: Figure mitotic entry

Entry into the final mitotic phase of the cell cycle.

Passage through the G2/M boundary depends upon the cyclin B/cyclin-dependent kinase 1 (CDK1) complex that is inactivated during G2, but is activated by a series of steps as the cells enter prophase (see the text for further details). The operation of the spindle-assembly checkpoint that prevents premature separation of the chromosomes is described in Module 9: Figure spindle assembly checkpoint.