High resolution

Module 9: Figure T cell chemotaxis

T cell migration towards antigen-presenting cells through a process of chemotaxis.

Antigen-presenting cells release cytokines that attract T cells. When they reach the antigen-presenting cell, they form the immunological synapse where the T cell receptor (TCR) on the T cell binds to the major histocompatibility complex II (MHCII) molecules on the antigen-presenting cell. The antigenic peptide (shown in red) is held on the surface of the MHCII molecules. Details of the synapse are shown in Module 9: Figure immunological synapse.