High resolution

Module 9: Figure G1 checkpoint signalling



G1 checkpoint signalling mechanisms.

Ionizing radiation causes double-strand breaks (DSBs) that induce two major DNA damage signalling pathways that arrests cells in the G1 phase of the cell cycle. The DNA-protein kinase (DNA-PK) signalling system (a–c). The ATM/checkpoint 2 signalling pathway (1–7).