High resolution

Module 8: Figure smooth muscle cell differentiation

Control of smooth muscle differentiation.

Smooth muscle cells (SMCs) are highly plastic in that they can readily switch from a highly differentiated contractile smooth muscle phenotype to a more fibroblast-like proliferative phenotype. Serum-response factor (SRF), working together with the miR-143/miR-145 cluster, controls this proliferation/differentiation switch.