High resolution

Module 8: Figure signalsome expression

Selective expression of a cell-specific signalsome.

Cells have access to a very large toolkit of signalling components, from which they select out and express specific components to create a cell-specific signalsome. The examples used here show how the selection of different components create cardiac- and T cell-specific signalsomes. The former produces a fast Ca2+ transient that occurs in less that 1 s, whereas the T cell transient lasts very much longer. CaM, calmodulin; CR, calreticulin; Et-1R, endothelin-1 receptor; IL-2R, interleukin-2 receptor; IP3R1, inositol 1,4,5-trisphosphate receptor 1; L-type, an L-type Ca2+ channel; PI 3-K, PtdIns 3-kinase; PLCβ1, phospholipase β1 (PLCβ1); PV, parvalbumin; SERCA, sarco/endo-plasmic reticulum Ca2+-ATPase; TCR, T cell receptor; TnC, troponin C.