High resolution

Module 8: Figure proliferation–differentiation switch

Function of inhibitor of DNA binding proteins (Ids) in proliferation–differentiation switch.

The Ids proteins promote proliferation by decreasing expression of the cyclin-dependent kinase (CDK) inhibitor Ink4a and prevent differentiation by sequestering transcription factors such as (E47 and E2A). Destruction of Ids by the anaphase-promoting complex (APC) liberates these transcription factors to begin the process of differentiation.