High resolution

Module 8: Figure planar cell polarity signalling

Planar cell polarity signalling mechanisms in Drosophila.

A working hypothesis concerning how the putative planar cell polarity signalling components might be organized in Drosophila through the operation of two parallel signalling pathways. A. The Frizzled (Fz)/Flamingo (Fmi) polarity signalling pathway may contribute to planar cell polarity by activating the actin/myosin contractile system. B. The Dachsous (Ds)/Fat (Ft) polarity signalling pathway depends on heterophilic interactions formed between the atypical cadherins Ds and Ft. This figure is based on information contained in Lawrence et al. (2007).