High resolution

Module 8: Figure osteoclast Ca2+ oscillations

Osteoclast precursor cell Ca2+ signalling.

Wild-type (WT) osteocyte precursor cells that have been stimulated with receptor activator of nuclear factor κB (NF-κB) ligand (RANKL) and colony-stimulating factor-1 (CSF-1) display oscillatory Ca2+ signals. Such oscillations are completely absent in cells from mice, where the adaptor protein DNAX-activating protein 12 (DAP12) has been knocked out (DAP12−/−). Reproduced by permission from Macmillan Publishers Ltd: Koga, T., Inui, M., Inoue, K., Kim, S., Suematsu, A., Kobayashi, E., Iwata, T., Ohnishi, H., Matozaki, T., Kodama, T., Taniguchi, T., Takayanagi, H. and Takai, T. (2004) Costimulatory signals mediated by ITAM motif cooperate with RANKL for bone homeostasis. Nature 428:758–763. Copyright (2004); http://www.nature.com; see Koga et al. 2004.