Module 8: Figure nodal structure

Structural organization of the node where left–right asymmetry is determined.

These scanning electron micrographs illustrate the triangular organization of the node, with its apex towards the anterior (A). Panels A and C are from a wild-type mouse, showing that the surface of the nodal cells have a single primary cilium (white arrows in the higher magnification picture in C). Panels B and D are from a kif3B−/− embryo, where the nodal cells lack cilia. Reproduced from Cell, Vol. 95, Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. and Hirokawa, N., Randomization of left–right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF38 3B motor protein, pp. 829–837. Copyright (1998), with permission from Elsevier; see Nonaka et al. 1998.