High resolution

Module 8: Figure coupled cell cycle/Ca2+ oscillator

The periodic activation of mitosis might be driven by an interaction between a Ca2+ and a cell cycle oscillator.

The Ca2+ oscillator depends upon the periodic release of Ca2+ from the endoplasmic reticulum (ER) that occurs spontaneously at the time of mitosis. The cell cycle oscillator depends upon the periodic proteolysis of cyclin through a process controlled by Ca2+. These two oscillators interact with each other, as described in the text.