High resolution

Module 8: Figure cardiac development

Development of cardiac cells.

The myogenic differentiation transcription factors serum-response factor (SRF), myocyte-enhancer factor 2 (MEF2) and MyoD activate the expression of the cardiac genes that emerge during the process of myoblast differentiation. These transcription factors also activate the miR-1 and miR-133 clusters and these two miRNAs contribute to the process of differentiation by helping to suppress cardiomyocyte proliferation and to fine-tune the expression of many cardiac components such as those functioning in cardiac conduction.