High resolution

Module 8: Figure bone marrow

Location and function of haematopoietic stem cells (HFCs) in bone marrow.

The haematopoietic stem cell (HSC) occupies two main niches within the bone marrow. The quiescent HSCs reside with the osteoblast niche where they associate with the spindle-shaped N-cadherin positive osteoblastic (SNO) cell. They can leave this niche (mobilization) to enter the blood and they can return (homing) to take up residence in empty niches. The HSCs also produce the progenitor cells that reside in the vascular niche where they proliferate to produce the cells that then differentiate into the haematopoietic cells (Module 8: Figure haematopoiesis). FGF-4, fibroblast growth factor-4; NA, noradrenaline; SCF, stem cell factor