High resolution

Module 8: Figure Satellite cell function

Satellite cells function in skeletal muscle repair and regeneration.

Satellite cells located beneath the basal lamina function in muscle repair and regeneration: 1. Following exercise or muscle damage, satellite cells are activated and begin to proliferate (Module 8: Figure Satellite cell activation). 2. Some of the divisions are asymmetrical such that one cell remains as a stem cell (red) while the other becomes a progenitor cell (green). 3. The progenitor cell continues to proliferate. 4. The progenitor cells stop proliferating and begin to differentiate into myoblasts that either fuse with the existing muscle or escape across the basal lamina and then fuse to form a new myofibre.